Masters Thesis: Creating Control Fields for a Point-of-Care Infection Test

07.04.2026, Abschlussarbeiten, Bachelor- und Masterarbeiten

The student must ensure test reliability, interpretability, and clinical relevance by enabling internal validation of sample flow, reagent activity, and environmental stability. The work focuses on translating laboratory-grade controls into a scalable, user-independent PoC format suitable for real-world diagnostic settings.

This project can run from 6 - 12 months.

Requirements:
- Proven previous laboratory experience, microbiology experience preferred.
- An applied, industry-aware mindset, balancing scientific rigor with manufacturability and usability.
- Practical expertise in image analysis, quantitative readout extraction, and time-resolved data evaluation.
- Independent working style and willingness to learn.

Project Goals:
- Designing control fields that reliably indicate correct test function under varying biological and environmental conditions.
- Integrating controls into an existing paper-based diagnostic architecture without increasing user complexity.
- Quantitatively evaluate control performance using image-based readouts and time-series analysis.
- Establish design rules and validation criteria aligned with regulatory expectations for PoC diagnostics.
- Scientifically validate with the most common laboratory bacterial strains seen in Urinary Tract Infections.
- Perform clinical validation with real human urine samples.

BugSense
Heinz-Nixdorf-Chair for Biomedical Electronics
Einsteinstraße 25, 81675 Munich

Kontakt: seoras.russell@tum.de