Master´s Thesis / Bachelor´s Thesis / research internship: Fungal biotechnology
Characterization and optimization of enzyme production by unconventional fungi
26.02.2026, Abschlussarbeiten, Bachelor- und Masterarbeiten
The thesis or research internship will focus on optimizing enzyme production in a unconventional fungal strain. Enzyme production will be analyzed using specific enzyme activity assays. In addition, genomic and proteomic data will be used to supplement the analysis.
The Werner Siemens Chair of Synthetic Biotechnology at the Department of Chemistry at the Technical University of Munich in Garching focuses on the isolation, characterization and process-oriented optimization of enzymes and microorganisms for the production of industrial platform chemicals. A key research area is the fermentation of filamentous fungi with the aim of producing extracellular proteins, natural products and pigments for a variety of industrial applications.
Your responsibilities:
• Cultivation and characterization of unconventional filamentous fungal strains
• Performance of various enzyme assays (e.g. lipase, cellulase, protease, amylase)
• Optimization of enzyme production in a filamentous fungal strain in liquid culture using statistical experimental design
• DNA isolation, whole genome sequencing (PacBio HiFi sequencing) and analysis of genomic data
• Generation of proteomic data (LC-MS/MS) for analysis of fungal enzyme production
• Upscaling of the optimized fermentation process (up to 50 L)
Your qualifications:
We are looking for a self-motivated, team-oriented, and well-structured individual with experience in biochemistry, biotechnology or microbiology. Previous experience in cultivation of microorganisms and with molecular biology methods are advantageous. We look forward to receiving your application documents.
Contact information:
Annika Krimmel, M.Sc.
annika.krimmel@tum.de
Werner Siemens-Lehrstuhl für Synthetische Biotechnologie (WSSB)
Department Chemie, Technische Universität München (TUM)
Lichtenbergstraße 4, 85748, Garching bei München
Kontakt: annika.krimmel@tum.de
Mehr Information
https://www.ch.nat.tum.de/wssb/startseite/