Master’s Thesis: Simulation of Fiber-Optic Ultrasound Detection for Non-Invasive Optoacoustic Spectroscopy
27.11.2025, Abschlussarbeiten, Bachelor- und Masterarbeiten
As part of the EU-funded GLUMON project, we are developing a novel approach for non-invasive glucose monitoring based on optoacoustic mid-infrared spectroscopy. This technology has the potential to enable continuous and pain-free blood glucose measurement — a real step forward in diabetes care. The main goal of this development is further miniaturization and an alternative to the current transmission mode measurement. You will investigate the combination of mid-infrared spectroscopy and fiber-optic ultrasound detection using COMSOL Multiphysics. Your work will greatly enhance existing simulations of the two regimes and combine them to identify key performance indicators for a miniaturized non-invasive glucose probe. Thesis Objectives The goal of this thesis is to develop and enhance existing simulations for fiber-optic ultrasound detection in combination with mid-IR excitation. The outcome of your simulation will be directly applied in an experimental setup with the option for you to conduct these experiments on your own. Tasks • Literature review of ultrasound propagation and interaction with different materials, optoacoustic signal generation • Development of a COMSOL simulation that integrates both domains of optoacoustics • Characterization and validation of the model with experimental data • If desired: experiments can be performed by you! Requirements • Enrolled Master’s student (m/f/d) in Physics, Computer Science, Data Science, Electrical Engineering, Mechanical Engineering or a related field • Solid programming skills in Python or MATLAB • Good understanding of optical and acoustic principles • Experience with COMSOL What We Offer • Opportunity to contribute to a cutting-edge, interdisciplinary research topic with real-world impact • Exposure to both academic research and practical applications through collaboration with a MedTech startup • Flexible working conditions (on-site lab work and remote work possible) Interested? Send an E-Mail including a Letter of Motivation and your latest Transcript of Records to: maximilian.gotsch @tum.de Maximilian Gotsch (Chair of Biological Imaging, Institute for Biological and Medical Imaging) TranslaTUM, Einsteinstraße 25, 81675 München
Master’s Thesis: Simulation of Fiber-Optic Ultrasound Detection for Non-Invasive Glucose Monitoring
As part of the EU-funded GLUMON project, we are developing a novel approach for non-invasive glucose monitoring based on mid-infrared optoacoustic spectroscopy. This technology aims to enable continuous and pain-free blood glucose measurement and represents a meaningful step forward in diabetes care.
In this thesis, you will investigate the combination of mid-infrared spectroscopy and fiber-optic ultrasound detection using COMSOL Multiphysics. Your work will contribute to an in-silico study of a miniaturized non-invasive glucose probe.
Thesis Objectives
Development and refinement of simulation models for mid-IR optoacoustic excitation combined with fiber-optic ultrasound detection. The results of your simulation will be compared to available experimental data. Experimental validation can optionally be carried out by you if you are interested in a combined simulation and lab-based thesis.
Tasks
- Conduct a literature review on optoacoustic signal generation and ultrasound propagation in different media
- Develop and refine a coupled simulation in COMSOL Multiphysics
- Validate your results against existing experimental data
- Optional: acquire and characterize additional experimental data in our laboratory if this aligns with your interests
Requirements
- Master’s student (m/f/d) in Physics, Computer Science, Electrical Engineering, Mechanical Engineering or a related field
- Solid programming skills in Python or MATLAB
- Good understanding of optical and acoustic (ultrasound) principles
- Experience with COMSOL is a big plus
What We Offer
- The opportunity to contribute to a cutting-edge, interdisciplinary research topic with real-world impact
- The freedom to shape the focus of the thesis according to your strengths and interests while receiving structured guidance and support
- Access to a state-of-the-art technology laboratory for simulation and experimental work
- Collaboration with a MedTech startup
- Flexible working conditions including a mix of on-site and remote work
Interested?
Send an E-Mail including a Letter of Motivation and your latest Transcript of Records to: maximilian.gotsch@tum.de
Kontakt: maximilian.gotsch@tum.de
Mehr Information
https://www.helmholtz-munich.de/ibmi/ibmi-biochemical-and-environmental-sensors