Master’s Thesis: Simulation of Fiber-Optic Ultrasound Detection for Non-Invasive Optoacoustic Spectroscopy

27.11.2025, Abschlussarbeiten, Bachelor- und Masterarbeiten

As part of the EU-funded GLUMON project, we are developing a novel approach for non-invasive glucose monitoring based on optoacoustic mid-infrared spectroscopy. This technology has the potential to enable continuous and pain-free blood glucose measurement — a real step forward in diabetes care. The main goal of this development is further miniaturization and an alternative to the current transmission mode measurement. You will investigate the combination of mid-infrared spectroscopy and fiber-optic ultrasound detection using COMSOL Multiphysics. Your work will greatly enhance existing simulations of the two regimes and combine them to identify key performance indicators for a miniaturized non-invasive glucose probe. Thesis Objectives The goal of this thesis is to develop and enhance existing simulations for fiber-optic ultrasound detection in combination with mid-IR excitation. The outcome of your simulation will be directly applied in an experimental setup with the option for you to conduct these experiments on your own. Tasks • Literature review of ultrasound propagation and interaction with different materials, optoacoustic signal generation • Development of a COMSOL simulation that integrates both domains of optoacoustics • Characterization and validation of the model with experimental data • If desired: experiments can be performed by you! Requirements • Enrolled Master’s student (m/f/d) in Physics, Computer Science, Data Science, Electrical Engineering, Mechanical Engineering or a related field • Solid programming skills in Python or MATLAB • Good understanding of optical and acoustic principles • Experience with COMSOL What We Offer • Opportunity to contribute to a cutting-edge, interdisciplinary research topic with real-world impact • Exposure to both academic research and practical applications through collaboration with a MedTech startup • Flexible working conditions (on-site lab work and remote work possible) Interested? Send an E-Mail including a Letter of Motivation and your latest Transcript of Records to: maximilian.gotsch @tum.de Maximilian Gotsch (Chair of Biological Imaging, Institute for Biological and Medical Imaging) TranslaTUM, Einsteinstraße 25, 81675 München

As part of the EU-funded GLUMON project, we are developing a novel approach for non-invasive glucose monitoring based on optoacoustic mid-infrared spectroscopy. This technology has the potential to enable continuous and pain-free blood glucose measurement — a real step forward in diabetes care.
The main goal of this development is further miniaturization and an alternative to the current transmission mode measurement. You will investigate the combination of mid-infrared spectroscopy and fiber-optic ultrasound detection using COMSOL Multiphysics. Your work will greatly enhance existing simulations of the two regimes and combine them to identify key performance indicators for a miniaturized non-invasive glucose probe.

Tasks
• Literature review of ultrasound propagation and interaction with different materials, optoacoustic signal generation
• Development of a COMSOL simulation that integrates both domains of optoacoustics
• Characterization and validation of the model with experimental data
• If desired: experiments can be performed by you!

Requirements
• Enrolled Master’s student (m/f/d) in Physics, Computer Science, Data Science, Electrical Engineering, Mechanical Engineering or a related field
• Solid programming skills in Python or MATLAB
• Good understanding of optical and acoustic principles
• Experience with COMSOL

What We Offer
• Opportunity to contribute to a cutting-edge, interdisciplinary research topic with real-world impact
• Exposure to both academic research and practical applications through collaboration with a MedTech startup
• Flexible working conditions (on-site lab work and remote work possible)

Interested?
Send an E-Mail including a Letter of Motivation and your latest Transcript of Records to: maximilian.gotsch @tum.de
Maximilian Gotsch (Chair of Biological Imaging, Institute for Biological and Medical Imaging)
TranslaTUM, Einsteinstraße 25, 81675 München

Kontakt: maximilian.gotsch@tum.de