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24.03.2026

Abschlussarbeiten, Bachelor- und Masterarbeiten:
Conservative Reachability Analysis for Uncertain Attitude Dynamics on SO(3)   

This thesis investigates conservative reachability analysis for uncertain rigid-body attitude dynamics on SO(3), motivated by autonomous on-orbit servicing of tumbling satellites. It aims to develop mathematically rigorous methods for computing guaranteed over-approximations of future target spacecraft orientations under uncertainty. The work combines classical reachability theory with geometric modeling and validation on realistic orbital scenarios.
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Kontakt: alessandro.melone@dlr.de

24.03.2026

Interne Jobbörse der TU München:
Gruppenleiter (m/w/d) Infrastruktur Instrumentierung   

Als Leiter der Gruppe Infrastruktur Instrumentierung an der Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRM II) suchen wir einen promovierten Experimentalphysiker in Vollzeit (40h / Woche). 
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Kontakt: personal@frm2.tum.de

24.03.2026

hoprae:
  

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24.03.2026

Interne Jobbörse der TU München:
Doctor thesis for medical students / Master`s Thesis Opportunity: “Strategic Enhancement of CAR-T Therapy for Resistant Pancreatic Cancer via Patient-Derived Organoids”, research group of Dr. Andrea Schmidts   

Master’s / Medical Doctoral Thesis Opportunity 16.03.2026 – Doktorarbeiten für Humanmediziner und Masterarbeiten We are offering an exciting opportunity for a highly motivated student to contribute to an ongoing project investigating the challenges of CAR-T cell therapy in the context of Pancreatic Ductal Adenocarcinoma (PDAC). ________________________________________ Project Overview Pancreatic ductal adenocarcinoma (PDAC) is characterized by profound resistance to therapy. Despite advances in systemic treatments, the five-year survival rate remains below 15%. Cellular immunotherapies such as Chimeric Antigen Receptor T-cell Therapy have shown remarkable success in hematologic malignancies, but their application in solid tumors has been limited by antigen heterogeneity, a dense stromal barrier, and T-cell exhaustion within the immunosuppressive tumor microenvironment. This study aims to address these barriers by developing CAR-T cells that will be evaluated in patient-derived organoid (PDO) co-cultures and in a Chorioallantoic Membrane Assay xenograft model. The research group of AG Schmidts has extensive expertise in CAR-T cell design, largely due to Dr. Andrea Schmidts’ long-term scientific experience. This project is a collaboration between AG Reichert and AG Schmidts. Through Prof. Reichert’s research group, we have access to a curated biobank of PDAC PDOs derived from surgical resections and biopsy specimens. Organoid cultures faithfully recapitulate key histological and molecular characteristics of the original tumors while preserving intratumoral heterogeneity. Using a panel of PDAC organoid cultures, we are able to evaluate the efficacy of our CAR-T cells in a robust experimental system across diverse tumor backgrounds. Co-culture experiments with PDAC PDOs and CAR-T cells provide a biologically relevant platform to investigate CAR-T cell proliferation, cytolytic activity, and exhaustion dynamics. To further assess therapeutic potential in a more complex setting, the project employs an in vivo xenograft approach using the chicken CAM model. This system provides a rapid and accessible platform for evaluating CAR-T cell performance prior to more advanced preclinical studies. Furthermore, the project explores strategies targeting tumor-associated extracellular matrix components. Specifically, oncogenic splice variants overexpressed in PDAC stroma are being investigated as tumor-selective CAR-T targets. By combining advanced organoid models, targeted CAR-T engineering, and microenvironment-focused strategies, this research aims to develop combinatorial CAR-T therapies for pancreatic cancer. Ultimately, the goal is to improve CAR-T cell infiltration and cytolytic efficacy and to establish translational approaches that may significantly expand the therapeutic potential of cellular immunotherapy in PDAC and other resistant solid tumors. ________________________________________ Your Responsibilities • Culture tumor cell lines • Maintain patient-derived organoids • CAR-T cell production (Cloning and large-scale plasmid preparation, virus production, T-cell transfection) • Generatex knockout (KO) cell lines using nucleofection • Extract RNA/DNA for conventional PCR and qRT-PCR • Analyze gene expression • Perform flow cytometry experiments on CAR-T cell co-cultures, organoids, and organs isolated from chicken embryos • Perform killing assays (luciferase-, FACS-, or Incucyte-based) ________________________________________ What We Offer • One-month internship before the start of the official contract • An international, collaborative, and dynamic research environment • Direct supervision and mentoring throughout the project • Technical support from a postdoctoral researcher (medical doctor) • Opportunity to contribute to peer-reviewed scientific publications • Participation in journal clubs and project-related meetings Students without extensive wet-lab experience are welcome to apply. While previous laboratory experience is beneficial, training in the relevant techniques will be provided. ________________________________________ Candidate Profile • We are looking for a motivated student who demonstrates: • Structured Work Approach • Strong organizational skills • Careful documentation of experiments, protocols, and results • Ability to work independently • Proactive attitude and responsibility for project progress • Strong interest in oncology and/or immunology Experience with some of the following techniques is helpful but not mandatory: • Primary cell culture • RNA/DNA extraction • Flow Cytometry • qRT-PCR • Plate-reader-based assays ________________________________________ How to Apply Please submit: • CV • Academic transcripts • A brief statement of interest outlining your motivation and relevant experience For inquiries and applications, please contact: Dr. Rebeka Javorniczky
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Kontakt: rebeka.javorniczky@tum.de

24.03.2026

Abschlussarbeiten, Bachelor- und Masterarbeiten:
Kosten-Nutzen-Risiko-Analyse vereinfachter Löschanlagen zu geregelten Löschanlagen   

Ein erheblicher Teil des Gebäudebestands kann heutige bauordnungsrechtliche Anforderungen nur mit hohem baulichem und finanziellem Aufwand erfüllen. In solchen Fällen werden anlagentechnische Kompensationsmaßnahmen diskutiert, insbesondere vereinfachte Löschanlagen.