Wissenschaftliches Personal, Doctoral thesis position (TV-L E13, 75%)
04.12.2025, Wissenschaftliches Personal
We invite applications for a doctoral position (TV-L E13, 75%) within the framework of the TUM Institute for Advanced Study (TUM-IAS) Hans-Fischer Senior Fellowship and the Focus Group “In-cell ¹⁹F NMR of Protein Interactions.” The project is a collaboration between Profs. Michael Sattler and Franz Hagn at the Bavarian NMR Center (BNMRZ, www.bnmrz.org), Technical University of Munich (TUM), and Prof. Angela M. Gronenborn, TUM-IAS Hans-Fischer Senior Fellow and University of Pittsburgh. This interdisciplinary research aims to advance protein and RNA structural biology and drug interactions by developing and applying innovative ¹⁹F NMR methodologies to study biomolecular structure, dynamics, and interactions in complex environments and live mammalian cells. By combining ultra-high-field NMR with complementary biochemical, computational, and cellular approaches, the project will overcome current limitations in sensitivity and contrast, enabling unprecedented insights into biomolecular mechanisms and protein–drug interactions in their native context. Building on established methods for site-specific fluorine incorporation in proteins and RNAs, leveraging fluorine’s central role in pharmaceutical research, the project offers the opportunity to contribute to transformative advances in in-cell biomolecular NMR studies. The successful candidate will work closely with experts from the BNMRZ, the Center for Functional Protein Assemblies (CPA), and the TUM Schools of Natural Sciences and Medicine and Health and will spend several months in the laboratory of Prof. Angela M. Gronenborn at the University of Pittsburgh (USA) to gain hands-on experience in complementary in-cell NMR and tailored biochemical techniques. Your Profile • Master’s degree (or equivalent) in Biochemistry, Biophysics, Structural Biology, Chemistry, or a related discipline • Strong interest and background in biomolecular NMR spectroscopy, protein biochemistry, and structural biology • Experience in recombinant protein expression, biophysical assays, or cell-based studies is advantageous • High motivation for interdisciplinary collaboration, great team spirit and communication skills • Excellent written and spoken English We Offer • A doctoral position (TV-L E13, 75%) at the Technical University of Munich in a vibrant, interdisciplinary research environment • Supervision and mentorship by internationally recognized experts in NMR spectroscopy, membrane biochemistry, structural biology and drug discovery • Access to state-of-the-art infrastructure at the Bavarian NMR Center, including ultra-high-field NMR spectrometers up to 1.2 GHz • Integration within the TUM-IAS Focus Group “In-cell ¹⁹F NMR of Protein Interactions”, fostering collaboration between TUM and the University of Pittsburgh • The unique opportunity to conduct part of the research in Prof. Gronenborn’s laboratory at the University of Pittsburgh • Opportunities for international networking and participation in advanced NMR methodology development with direct biomedical applications
We invite applications for a doctoral position (TV-L E13, 75%) within the framework of the TUM Institute for Advanced Study (TUM-IAS) Hans-Fischer Senior Fellowship and the Focus Group “In-cell ¹⁹F NMR of Protein Interactions.”
The project is a collaboration between Profs. Michael Sattler and Franz Hagn at the Bavarian NMR Center (BNMRZ, www.bnmrz.org), Technical University of Munich (TUM), and Prof. Angela M. Gronenborn, TUM-IAS Hans-Fischer Senior Fellow and University of Pittsburgh.
This interdisciplinary research aims to advance protein and RNA structural biology and drug interactions by developing and applying innovative ¹⁹F NMR methodologies to study biomolecular structure, dynamics, and interactions in complex environments and live mammalian cells. By combining ultra-high-field NMR with complementary biochemical, computational, and cellular approaches, the project will overcome current limitations in sensitivity and contrast, enabling unprecedented insights into biomolecular mechanisms and protein–drug interactions in their native context.
Building on established methods for site-specific fluorine incorporation in proteins and RNAs, leveraging fluorine’s central role in pharmaceutical research, the project offers the opportunity to contribute to transformative advances in in-cell biomolecular NMR studies. The successful candidate will work closely with experts from the BNMRZ, the Center for Functional Protein Assemblies (CPA), and the TUM Schools of Natural Sciences and Medicine and Health and will spend several months in the laboratory of Prof. Angela M. Gronenborn at the University of Pittsburgh (USA) to gain hands-on experience in complementary in-cell NMR and tailored biochemical techniques.
Your Profile
• Master’s degree (or equivalent) in Biochemistry, Biophysics, Structural Biology, Chemistry, or a related discipline
• Strong interest and background in biomolecular NMR spectroscopy, protein biochemistry, and structural biology
• Experience in recombinant protein expression, biophysical assays, or cell-based studies is advantageous
• High motivation for interdisciplinary collaboration, great team spirit and communication skills
• Excellent written and spoken English
We Offer
• A doctoral position (TV-L E13, 75%) at the Technical University of Munich in a vibrant, interdisciplinary research environment
• Supervision and mentorship by internationally recognized experts in NMR spectroscopy, membrane biochemistry, structural biology and drug discovery
• Access to state-of-the-art infrastructure at the Bavarian NMR Center, including ultra-high-field NMR spectrometers up to 1.2 GHz
• Integration within the TUM-IAS Focus Group “In-cell ¹⁹F NMR of Protein Interactions”, fostering collaboration between TUM and the University of Pittsburgh
• The unique opportunity to conduct part of the research in Prof. Gronenborn’s laboratory at the University of Pittsburgh
• Opportunities for international networking and participation in advanced NMR methodology development with direct biomedical applications
Die Stelle ist für die Besetzung mit schwerbehinderten Menschen geeignet. Schwerbehinderte Bewerberinnen und Bewerber werden bei ansonsten im wesentlichen gleicher Eignung, Befähigung und fachlicher Leistung bevorzugt eingestellt.
Hinweis zum Datenschutz:
Im Rahmen Ihrer Bewerbung um eine Stelle an der Technischen Universität München (TUM) übermitteln Sie personenbezogene Daten. Beachten Sie bitte hierzu unsere Datenschutzhinweise gemäß Art. 13 Datenschutz-Grundverordnung (DSGVO) zur Erhebung und Verarbeitung von personenbezogenen Daten im Rahmen Ihrer Bewerbung. Durch die Übermittlung Ihrer Bewerbung bestätigen Sie, dass Sie die Datenschutzhinweise der TUM zur Kenntnis genommen haben.
Kontakt: Please send your CV, motivation letter, academic transcripts, and contact details of two referees as a single PDF file to: franz.hagn@tum.de and michael.sattler@tum.de. Applications will be reviewed on a rolling basis, and the position will be filled as soon as possible.